I´m getting a 5-15 sec lag when starting Paint.net 3.5.1 in Windows 7 RC b7260 32-bit with the latest Vandermotten plugins (with all or a single dll). There´s no CPU usage and no plugin load errors, the app just doesn´t respond for 5-15 sec.
My rig:
Pentium Dual Core E2180
3GB RAM
160GB HDD