I use Paint.Net to draw street maps of my neighbourhood, in Bucharest, Romania. I started this project about 8 mounths ago and i'm very pleased about the posibilities of that software. Also, i use it to crop photos or to write adnotations on them.
Recently i've bought a Genius G-Pen F610 graphic (drawing) tabet. I'm very pleased about how it works under Vista and Office 2007, but i needed to draw my maps with it under Paint.NET. So, i've tested, and i found it didn't work very well.
First of all, drawing is not fluid, like on other programs. I've tried both paintbrush and pencil, but