Hey now, if I got rid of something every time it broke I wouldn't be using Paint.NET now would I? v4.2.2, v4.2.3, v4.2.4 (and I bet v4.2.5 is right around the corner too), so Ha!
And just to clarify, I use the AV that I do because it give ME the full control on MY System on what should and what does happen with its HIPS, unlike Windows Defender and pretty much any other MS product where you have no control over anything. So yeah, it wasn't due to the file being malicious (maybe I should have clarified this part better), I knew it was an MS file from the get go, it simply informed me that this .dll was trying to load and I looked at it and said, Na, block it, previous version of Paint.NET didn't use this thing so why allow some new .dll to run for v4.2.4.
Maybe you like the hands off approach with Defender, but I love having a super tight Firewall and HIPS rule set that gives me the control.
Also Windows Defender is IMO trash, it has some of the worst performance of all the AV's, what with it having no caching thus it will constantly scan the same files over and over every time you open a folder for example, obtuse and hidden settings that are only accessibility with PowerShell, and like I said above, gives the user almost no control over how it works, hope you like definition updated updating 5+ times a day... Oh and they currently sit on top with the most false positives, so congrats to them on that achievement!
Small Edit: Oh and I also find it funny how you say, your AV's broken use WD, when recently MS broke WD.