I only have one PC i7-6700K & 16GB, the 4.0.9 version works as it should, but the 4.0.10 only use 50-65% of the cpu as a result being slower, according to my measurements it is around 25-30% slower than the 4.0.9.(btw the 80sec vs 50sec was a typo I meant 80sec vs 60sec, and that was the TjacksonEffects.dll)
image size: 18600x9300
Number of layers: 12
I mostly use plugins but the performance hit was the same with effects/tools that was already there (even the basics, resize, flatten, open image, etc)