Let us know how you get on - I am in exactly the same boat, though having used Paint for over a year with no problems. Have followed all the suggestions and thought I'd got it completely clear, but when I get right to the end of a fresh installation I get the dreaded "Fatal Error" message. Whatever it is, it's hiding somewhere on my system despite auto uninstall followed by manual seraching for the bits. I've probably spent 6 or more hours this week alone trying to resolve it. A real shame as I've come to be very used to using paint.net and it looks like I'm going to have to learn a whole new package as I've got images I need worked on urgently. I've tried and tried with uninstalls, installs, removing .net and replacing it etc. It seems to stem from the last Beta I think.