After running Paint.NET last night, it prompted it me to update to the latest version - which I did.
Afterwards, however, if I tried to run Visual Studio 2008, I received the message:
Cannot find one or more components. Please reinstall.
Trying to repair 2008 with the install discs yielded this:
A problem has been encountered while loading the setup components. Cancelling setup.
The only thing I could do was to roll back the system to before Paint.NET update. I strongly suggest that you pull the update until this is resolved.
XP Professional. Fully patched. Latest .net assemblies.