EOEffects.dll is the library alright and it goes in C:\Program Files\Paint.NET\Effects. So far, so good ... but ...
These images come in series - 48 to a set in this animation. The shear action to give the isometric effect must be constant, and preferably with some sort of setting mechanism to guarantee that. Otherwise each frame has a card with a different shape ...
At present, I have to create the images in Paint.NET as GIF files, skew them in MSPaint as BMP files, then reconvert them to GIF files in Paint.NET. It works, but it's a bit of a drag. I'd be delighted to find that there is a plug-in for Paint.NET that handles the job in house.