A similar thing has happened to me. During a power cut my Canon MG7550 driver became corrupted so I installed one from the Canon site. Since then Paint.net has not found the scanner - the option is greyed out in Acquire. I uninstalled the downloaded driver and reinstalled the driver from the disc that came with the printer/scanner and that has not worked. I have tried downloading twainableplus and that has not worked. I use the scanner a lot in Paint.net and need to get it working again. I am using Windows 10