I am having the same issue as sithguy with the same exact stack trace but different version:
Application version: Paint.NET v3.36 (Final Release build 3.36.3158.38068)
I've tried reinstalling Paint.NET and the .NET Framework and still no luck.
I haven't altered my fonts and I don't really have the luxury of removing them all and restoring them somehow.
Any other ideas?
Thanks in advanced!