Perhaps I explained poorly. Right now, if I am working with a zoomed in image, one pixel in the image I am drawing corresponds to many pixels on my screen. And paint.net <i>does</i> behave differently depending on where in that region I click.
In order to explain, I need a definition. Since my image is zoomed in, one pixel of the image corresponds to a region of many pixels on my screen. Let's call this region the "pixel region."
Suppose I am in paint.net with a brush width of 1. If I click on the right side of the pixel region, what happens is that the corresponding pixel in my image gets recolored to a color closer to the primary color. However, the pixel to its immediate right is also recolored somewhat. It does not go all the way to the primary color, but it does go part way there. And the further to the right in the pixel region I click, the more the color changes.
It is difficult for me to click precisely in the center of the pixel region. I am wondering if there is any way to get paint.net to control for this.