Thanks for the suggestions, but it appears that no matter WHICH folder I naviagate to, as soon as I try to double-click a file to open it, Paint.net locks up after the double-click. Right now, I just went to My Pictures, tried to open a tiny jpg of homer simpson and all it did was lock up. Now if I ALT-TAB, Paint.net is not one of the ALT-TAB icons available, even though "Untitled (100%) -..." is still on the taskbar (from Paint.net).. So it appears the program is there, but not really there, or something. If it's not available as an ALT-TAB option, what could that mean?
I might try to uninstall, delete the Paint.net folder, run CCLEANER (a registry/system cleanup util) and try to install this again.. I'll let you know if that does any good.