Not sure, doesn't seem like much hardware-wise, I have reinstalled Paint.NET and I have the latest .NET framework installed (3.0). I've tried exiting all programs, and disabling Antivirus before running paint.NET but nothing seems to have any effect, the program just repetitively freezes throughout use.
My other two computers work perfectly with paint.NET
One is Pentium 4 630 HT, 1 GB RAM and a x300 Graphics; XP MCE
Other is a 3200+, 1GB RAM and x200 Graphics; XP Home
They both have .NET 1.1 and 2.0 installed