I'm not sure if it's a plugin-based issue, something with my hardware, or just Paint.net itself, but If I attempt any sort of adjustment such as brightness/contrast, hue/saturation, etc, it will freeze for a few seconds, and then completely crash, without any sort of trace in the crash logs.
I've attempted to reinstall the program a handful of times, clearing the cache, but to no avail.
I'm not sure if this helps, but I have attached diagnostics information here. It's currently version 4.3.10 if that means anything.
PDNDiagnostics.txt