Hi there,
Paint.net is my go-to to annotate screenshots of Windows or other things I'm working on, to highlight sections, point arrows, etc.
The usual procedure is to
grab an image to clipboard
open Paint.Net
CTRL-N (which reads the clipboard image dimensions) which then replaces the default empty image (it's great that it does that!)
CTRL-P to paste my clipboard image.
It'd save me the CTRL-N if Paint.net's default empty image dimensions were already based off the clipboard image (if any) dimensions.
Alternatives might be, like Affinity Photo - which doesn't start with a default image; the CTRL-ALT-SHIFT-N keyboard shortcut that simply creates a new image with the contents of the clipboard.
Cheers!