Same issue. Error "Windows 7 SP1, Windows 8.1, or Windows 10 (version 1607) is required."
Running today 2020-04-03, Windows 10 (business editions), version 1909 (updated March 2020). I think it happens on version 1903 as well.
paint.net.4.2.10.install.exe file version 4.210.7348.40816.