I have an RGBW monitor and cleartype is terrible. Paint.net seems to support GDI override and/or cleartext settings for rendering of the fonts, but the GUI itself is still a mess with artifacts that resemble an old Apple II. I've disabled system clear type. I've installed mactype and paint.net insists on using stock Windows cleartype.
https://cdn.discordapp.com/attachments/671896035622387725/691703306745151558/IMG_0457.JPG