Troy

Thank you everyone.

Thank you for the replies. I am a long time Paint.net user, but I also own the Affinity suite. Affinity Photo opens the file correctly. I tend to bounce back and forth between Paint.net and Affinity Photo. My solution has been opening in Affinity Photo, saving again as .PNG and then opening in Paint.net. If this is NOT a Paint.net bug, why does Affinity Photo open it without a problem? Also, Photopea also opens it without a problem.

I use a ClipDrop to upscale and remove backgrounds of images. I often get errors in Paint.net opening PNG files. Error, as in I can't open the file. Here is a sample file: https://drive.google.com/drive/folders/1xjtsxl8YDNt1LuBQlRlafnA6nJKUOrgv?usp=sharing Here is the copy/paste information from Paint.net to help troubleshoot.

Thank you both. Seems like I did a graphics card update, and it took over my hotkey for Paint.net without my permission. I know which one is more important! I disabled it immediately. User error! Back to using my old shortcut. Thank you both!

Bug: When you try and use the shortcut keys for "Save as" you get Instant Replay OFF. Annoying! Application paint.net 4.1.6 (Final 4.106.7016.38074) Build Date Monday, March 18, 2019 Install type Classic Hardware accelerated rendering (GPU) True Animations True DPI 96 (1.00x scale) Language en-US OS Windows 10 Pro x64 (10.0.17134.0) (0x30) .NET Runtime 4.0.30319.42000 Physical Memory 16,340 MB CPU Intel(R) Core(TM) i7-6700K CPU @ 4.00GHz Speed ~4008 MHz Cores / Threads 4 / 8 Features SSE, SSE2, SSE3, SSSE3, SSE4_1, SSE4_2, AVX, AVX2 Video Card AMD Radeon (TM) R9 Fury Series Dedicated Video RAM 4,071 MB Dedicated System RAM 0 MB Shared System RAM 8,170 MB Vendor ID 0x1002 Device ID 0x7300 Subsystem ID 0x0B361002 Revision 200 LUID 0x00009615 Flags AcgCompatible, SupportMonitoredFences, KeyedMutexConformance Graphics Preemption DmaBufferBoundary Compute Preemption DmaBufferBoundary Outputs 1 Feature Level Direct3D_12_0 DXGI Formats A8_UNorm, B8G8R8A8_UNorm, R16G16B16A16_UNorm, R16G16B16A16_Float, R32G32B32A32_Float Buffer Precision UNorm8bpc, UNorm8bpcSrgb, UNorm16bpc, Float16bpc, Float32bpc Video Card Microsoft Basic Render Driver Dedicated Video RAM 0 MB Dedicated System RAM 0 MB Shared System RAM 8,170 MB Vendor ID 0x1414 Device ID 0x008C Subsystem ID 0x00000000 Revision 0 LUID 0x0000A21A Flags Software, AcgCompatible, SupportMonitoredFences, KeyedMutexConformance Graphics Preemption InstructionBoundary Compute Preemption InstructionBoundary Outputs 0 Feature Level Direct3D_12_1 DXGI Formats A8_UNorm, B8G8R8A8_UNorm, R16G16B16A16_UNorm, R16G16B16A16_Float, R32G32B32A32_Float Buffer Precision UNorm8bpc, UNorm8bpcSrgb, UNorm16bpc, Float16bpc, Float32bpc