I noticed paint.net being very sluggish after the latest release when just moving around the mouse, so I turned on my monitor’s fps counter and it showed massive fps drops.
Sometimes when I leave the cursor still it slowly decreases further until it’s at 1 fps.
Once I move it again fps get better, but it's pretty random overall.
A short video of the behavior, please excuse the Blair Witch Project-cinematography ;):
https://streamable.com/vc8t8
It actually drops to 1 fps as mentioned but I was nearing the 30 second limit for Imgur(which later turned out to fail at the upload), so I didn't capture it on video.
As you can see at the start, it only happens when paint.net is in focus.
If I open any other program in the foreground, I can mouse over anything I want in paint.net in the background and the fps will stay high.
System:
3770K
16GB RAM
1060 6GB(driver version 416.94)
Win10 Pro 1809(build 17763.134)