How it works:
You hold a key on your keyboard and click on a checkbox in the layers window. When clicked all layers except for the layer you've clicked get disabled.
When you click on a layer which is the only layer that is enabled it toggles all layers on again using the same keybinding.
Example:
"alt+[checkbox]", "ctrl+[checkbox].
Why:
Paint.net is simple, i get that. But this shortcut could save someone like me a lot of time when showing some UI concept arts or something like that.