Thank you for your response. There's nothing more to be done here, but in return for responding to my questions, I think you deserve feedback. Twainable won't be useful to me with that limitation.
I used to use Paint Shop Pro as an image processing program, mainly for scanning documents and doing simple cleanup operations (flood fill of dirty backgrounds, etc). Windows 7 won't run my old version of PSP, and I found the current version to be a huge, complex thing in which everything is possible and nothing is easy. That started my search for a new image processing program. I thought Paint.NET would be it, but it won't. Its built-in scanner interface doesn't let me adjust contrast, brightness, or resolution;Twainable doesn't support the document feeder. From my point of view those are all utterly basic features, and a program that lacks any of them is simply not adequate for my needs.
I understand that there's nothing you can do about document feeder support due to the way Paint.NET forces you to interface with it. I don't know about the built-in interface. But you (and the Paint.NET developers) should be aware that these limitations essentially make the program useless to people for whom scanning is important.