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"1603" would have been a helpful detail. This means your installation of paint.net is broken. You can remove the broken installation with this tool: https://support.microsoft.com/en-us/mats/program_install_and_uninstall Afterwards, you should be able to install paint.net anew. If you have any further issues, you can take a look at this: https://forums.getpaint.net/index.php?/topic/110411-common-install-uninstall-crash-problems-and-solutions/