Update.
Thanks Administrators
Just received a Bug response from paint.net
"Microsoft broke something in their latest Visual Studio and C++ updates. It only affects some systems though.
To fix it, you can install this: https://www.microsoft.com/en-us/download/details.aspx?id=48145"
The message was
"The program can't start because api-ms-win-core-timezone-l1-1-0.dll is missing from your
computer. Try reinstalling the program to fix this problem."